Originally, many bacteria are crowded in the intestine to create an ecosystem. When food enters through the mouth, it is decomposed by saliva, gastric juice, pancreatic juice, etc., and is carried to the intestines in a form that is easily absorbed. It nourishes the bacteria, and we take in what the bacteria make and coexist. Like the fungus Candida, it’s nice to have a little, but if it gets too much, it’s very annoying and causes leaky gut syndrome. There are various kinds of people, such as lactic acid bacteria, who are kind and nice.

The area from the mouth to the anus is actually the outside world, and the intestinal mucosal epithelial cells are called tight junctions and do not allow foreign substances to enter from the outside world. It firmly forms a barrier.

  • Lactic acid bacteria and the Bacteroides tribe play a role in forming this barrier.
  • Bacterial diversity can prevent certain species from overgrowth.

When the intestinal bacteria become poor, the joints of the intestinal epithelial cells crack and loosen, just like in rough land, and they should enter through the gaps.

Toxins such as bad viruses, undigested proteins, and heavy metals that have not been completely decomposed enter the body.

How Leaky Gut Syndrome affects?

It is a syndrome that causes a number of terrifying symptoms and is said to begin with a hole in the intestine. The intestines are originally covered and protected by mucous membranes, which can become thin and punctured. By making a hole in the intestine, harmful substances such as bacteria and toxins that should not be taken into the body will be taken into the body, causing various symptoms.

What are the symptoms of Leaky Gut Syndrome?

  • Some intestinal diseases include irritable bowel syndrome and ulcerative colitis
  • Abdominal pain
  • Obesity
  • Women’s organ diseases such as uterine myoma and menopausal disorders
  • Allergic symptoms such as pollinosis, food allergies, asthma, and atopy
  • Mouth odor and body odor Deterioration, headache, fever, chronic stress, schizophrenia, depression, autism, etc. 

Causes of Leaky Gut Syndrome

Various factors are intricately intertwined in the cause of Leaky Gut Syndrome.
For example, due to daily stress, excessive intake of junk food and sugar-containing foods, and indigestion such as overeating, intestinal toxins damage the mucous membrane of the intestinal wall, making it easy for the intestine to leak easily (leaky gut).

Leaky gut is also said to be caused by painkillers, antibiotics, medicines such as steroids and pills, and daily factors such as alcohol and caffeine, nutritional deficiencies, and chronic stress.

These substances inflame the intestinal mucosa and damage the cells of the intestinal tract.
At that time, there is a gap in the “tight junction” (called a tight junction) that connects the cells.
Normally, these “joints” are tightly connected so that substances in the intestinal tract do not leak out of the intestinal tract.

How Leaky Gut Syndrome can be cured?

When the intake of protein is low and the intake of sugar is high, the good bacteria in the intestine decrease, and the bad bacteria increase, the nutrition in the intestine deteriorates. Bad bacteria have the property of accumulating mercury, which inhibits proteolytic enzymes to produce peptides, which further damage the intestinal wall and are absorbed into the blood. On the other hand, the absorption of nutrients such as essential minerals is hindered. Contamination with heavy metals and harmful minerals (mercury, lead, arsenic, cadmium) may cause microorganisms such as yeast and candid a to parasitize. Furthermore, long-term administration of antibiotics worsens the intestinal bacterial flora, thins the intestinal wall, and allows foreign substances and organisms to easily penetrate the intestinal wall in a state where intestinal immunity does not work sufficiently.

This is called “LGS” for short, “leaky gut syndrome” in a state where the intestine (gut) leaks (leak), and since bacteria move into the blood, a blood test for “LGS” In, the concentration of “Alkaline Phosphatase” (Japanese reading alkaline phosphatase abbreviation: ALP) in the serum may increase. ALP includes liver, kidney, osteoblasts, placenta, and small intestine. Cell regeneration is performed as a repair activity associated with necrosis and destruction from five organs, and along with this, ALP synthesis is enhanced and released into the blood. ALP is expected to rise.

Delayed allergies may also be involved in the cause of Leaky Gut Syndrome.

Treatment of Leaky Gut Syndrome

As a treatment, improving your eating habits is the most important thing. The intestines are, of course, greatly affected by what you eat. Therefore, it is important to refrain from sugar foods, food additives, yeast foods, unnecessary medicines, etc. that may damage the mucous membrane of the intestinal tract so that leaky gut does not progress any further.

It is often emphasized that if you do not chew food well, you will have poor digestion and will be prone to “leaky gut syndrome“. It is said that this causes food allergies, so it is important to chew well. Recently, the number of patients with allergies, chronic urticaria, and eczema is increasing, so chew well first.

If you live a stress-free life and your symptoms do not go away even if you eat as regularly as possible, there is also a treatment option called intestinal flora transplantation (fecal transplantation) to improve the intestinal environment.


Millions of people around the world are affected by a thyroid disease: for example, an enlarged thyroid gland, also called goiter. Overactive or underactive, or benign or malignant thyroid nodules. Some thyroid diseases can be treated with medication. Others, however, require thyroid surgery. During surgery, a neuromonitoring device can help protect nerves from injury.

Definition of Thyroid

The thyroid is located in the lower front part of the neck, just in front of the windpipe. It has the shape of a butterfly because it consists of two “lobes” that lie on either side of a thin strip of fabric. The nerves that control the vocal cords run just behind the thyroid. Usually, you can neither see nor feel the thyroid gland. However, if it is enlarged, a swelling forms on the neck: the goiter or goiter. With other thyroid diseases, a noticeable goiter does not necessarily have to form.

The thyroid gland produces, among other things, the two important hormones thyroxine (T4) and triiodothyronine (T3). These hormones play an important role in metabolism, i.e. in converting the food ingested into energy for the body. If the thyroid is not working properly, the body uses up energy too slowly or too quickly.


What thyroid diseases are there?

The most common thyroid disease is hypothyroidism. A basic distinction is made between congenital and acquired thyroid disorders. But it is much more important whether the thyroid gland produces too little or too many hormones. According to this, doctors differentiate between an underactive thyroid (too few hormones) and an overactive thyroid (too many hormones).

Several causes disturb the function of the thyroid gland: the organ is not properly developed, inflamed, or maligned. Well-known diseases of the thyroid are, for example:

  • Hashimoto’s thyroiditis
  • Graves disease
  • Thyroid autonomy
  • Inflammation of the thyroid gland
  • Thyroid cancer

The thyroid sometimes tries to compensate for functional disorders or too little iodine by enlarging into a goiter (goiter)Thyroid nodules may also form.

Causes of Thyroid diseases

Goiter (goitre)

A goiter (goitre) can have many causes, for example:

  • Graves’ disease – An autoimmune disease that can cause the thyroid gland to swell and become overactive.
  • Thyroiditis (inflammation of the thyroid gland), for example from a viral infection.
  • Iodine Deficiency – The thyroid needs iodine to produce hormones. With a diet low in iodine, the thyroid gland enlarges.
  • Medicines with active ingredients such as amiodarone, interferon-alpha, and lithium.
  • In some people, the tendency to have a large thyroid runs in their families.

Thyroid nodules 

Thyroid nodules (small swellings in the thyroid gland) can be of different types:

  • Cyst – a fluid-filled benign tumor
  • Adenoma – solid benign tumor
  • less often: thyroid carcinoma (malignant tumor)

Possible causes of an overactive thyroid (hyperthyroidism) are, for example, Grave’s disease or thyroid nodules.

The two most common causes of underactive thyroid (hypothyroidism) are autoimmune diseases (when white blood cells destroy the cells of the thyroid gland) and side effects of treating thyroid disease. Genetic factors, complications from viral infections, and the side effects of certain drugs rarely cause hypothyroidism.


Symptoms of Thyroid diseases


In hypothyroidism, the so-called hypothyroidism, the thyroid pours to small amounts of hormones. Symptoms of this condition include weight gain, tiredness, and feeling cold.

Hypothyroidism affects more women than men. The metabolic disorder is discovered usually between the ages of 40 and 60. The number increases with age. But children can also suffer from an underactive thyroid.

Tiredness, exhaustion, a swollen face, dry skin, and rough hair: These are typical symptoms of an underactive thyroid. A change in eating habits or weight gain can also be signs of thyroid disease.

In children, it is often less characteristic; for example, through listlessness, concentration and attention disorders, and obesity. A learning disability is often noticeable at school.

Hypothyroidism often requires taking tablets that contain thyroid hormones. Proper nutrition can also support thyroid function. With the right treatment, you can lose weight despite being underactive.


In contrast to hypothyroidism, the organ produces too many thyroid hormones when it is overactive.

The most common causes of hyperthyroidism are Graves’ disease and thyroid autonomy. In Graves’ disease, your immune system damages the thyroid. So, it is an autoimmune disease. Graves are more common in women than men and are usually diagnosed after the age of 35.

With thyroid autonomy, the organ, or at least parts of it, independently produces too many hormones. The risk of developing this thyroid disorder increases with age.

Typical symptoms of an overactive thyroid are hair loss, excessive sweating, tremors, racing heart, diarrhea or weight loss. In Graves’ disease, the inflammatory processes sometimes also protrude the eyes.

Special drugs, so-called thyreo statics, help against an overactive thyroid. Normal metabolism is achieved with this. Only then does the doctor plan to treat the actual cause, such as surgery or radioiodine therapy.

What are the symptoms of thyroid disease?

Thyroid hormones affect many processes in the body. If problems arise here, complaints can occur in different parts of the body. A Hashimoto’s thyroiditis is manifested by symptoms of hypothyroidism.

General symptoms of an underactive thyroid:

  • fatigue
  • Slightly cold
  • Weight gain, constipation
  • Sadness, depression
  • Slow heartbeat (bradycardia)

Graves’ disease can be recognized by the symptoms of an overactive thyroid, but patients with thyroid autonomy also suffer from it.

General symptoms of an  overactive thyroid gland:

  • Weight loss, diarrhea
  • Sweating, sensitivity to heat
  • Difficulty sleeping, poor concentration
  • Inner restlessness, tremor
  • Palpitations, palpitations

Those affected by Graves’ disease sometimes have protruding eyes (bulging eyes). They arise from an increase in connective tissue behind the eyeball. Doctors speak of endocrine orbitopathy.

Hyperthyroidism complaints, on the other hand, are also often complained by people who are sick with thyroid inflammation. Often, additional symptoms are:

  • Fever
  • Severe pain, swelling, redness, and overheating in the thyroid area
  • Radiating pain in jaw and ear
  • Difficulty swallowing (dysphagia)

In a thyroid often symptoms do not occur until later. Common symptoms include:

  • Thyroid nodules
  • Difficulty swallowing (dysphagia)
  • Persistent hoarseness
  • Stridor
  • Swelling of the lymph nodes

With any thyroid disease, the organ can also enlarge. Doctors then speak of a goiter. Thyroid enlargement is popularly known as goiter. It can occur through too little iodine alone (iodine deficiency goiter).

Risk factors for thyroid disease

Certain factors increase your risk of developing thyroid disease:

  • Gender – Women are six to eight times more likely to develop thyroid disease than men.
  • Age – From the age of 50, there is an increased risk of thyroid disease.
  • Thyroid problems during or after pregnancy, or thyroid disease in a close relative
  • Smoking – smokers (including former ones) have an increased risk of autoimmune thyroid disease.
  • Iodine deficiency
  • The body receives too much iodine from dietary supplements.
  • Certain forms of medical treatment and drugs
  • Excessive stress or high psychological and physical stress

Diagnosis of thyroid diseases

To diagnose thyroid disease, the doctor not only examines the thyroid gland but also other factors that can make thyroid problems noticeable: for example, skin, nails, hair, heart function, weight, or body temperature.

A blood test provides information about the level of thyroid hormones. An imaging exam, such as an x-ray, may also be needed. If a lump is found in the thyroid gland, the doctor can insert a fine needle into the lump. He takes cells for analysis and can determine whether the lump is benign or malignant.


What is Chronic Fatigue Syndrome?

Chronic Fatigue Syndrome is a condition in which general malaise and chronic fatigue that significantly impair daily life do not recover even after resting and continue for an extended period of 6 months or longer.

At the same time, infectious disease-like symptoms such as fever, lymphadenopathy, and sore throat, collagen disease-like symptoms such as headache, myalgia, arthralgia, weakness, sleep disorders, decreased thinking ability, depression, and anxiety, and various symptoms, also appear.

Chronic fatigue syndrome, also known as myopathic encephalomyelitis, is a disease concept proposed by the CDC (National Center for Disease Control) in 1988 as Chronic Fatigue Syndrome (CFS).

On the other hand, the same pathological condition is called ME (Myalgic Encephalomyelitis) in the United Kingdom and Canada. In recent years it is often described together with ME / CFS.

There are also reports that people prone to chronic fatigue syndrome have distinct psychological characteristics. The causes of the syndrome have not been clarified, but recent research has gradually revealed how it causes illness.

In our body, the autonomic nervous system, the hormonal system, and the immune system work balanced. However, when stress causes abnormalities in the autonomic nervous system, and hormonal system and the immune system is weakened, the virus latent in the body is reactivated.

Then, the body becomes overproduced with immune substances to suppress the reactivated virus.

This overproduced immune substance affects the brain’s work and causes inflammation of the brain. And the theory that inflammation of the brain causes a strong feeling of fatigue and various symptoms is predominant.

Therefore, chronic fatigue syndrome has been described as “myalgic encephalomyelitis/chronic fatigue syndrome” and inflammation of the brain.

What is the difference from normal tiredness?

Normal fatigue can be relieved by getting enough rest, such as a good night’s sleep and a well-balanced diet, and by supplementing with the missing nutrients.

 What are the diagnostic criteria for chronic fatigue syndrome?

Fatigue in Chronic Fatigue Syndrome is fatigue that does not recover even with adequate rest. The diagnostic criteria for chronic fatigue syndrome in SEID list three symptoms as essential conditions.

  • With chronic fatigue with a definite onset time, a significant decrease in pre-illness employment, educational background, social and personal activity levels is observed for more than six months.
  • Extreme fatigue that worsens after exertion.
  • Sleep disorders (sleep without a feeling of deep sleep or recovery)

  In addition, any of the following two symptoms is also a diagnostic criterion.

  • The decline in cognitive function
  • Orthostatic intolerance

 However, since the syndrome does not have exclusion criteria and a high prevalence rate, additional items may be added to establish clinical diagnostic criteria.

Treatment of Chronic Fatigue Syndrome

No cure for chronic fatigue syndrome has been established at this time, but the following treatments are being considered:

  • Antioxidant therapy
  • Immunostimulatory therapy (Chinese medicine, etc.),
  • Psychotherapy (SSRI, antidepressant, antidepressant, etc.)
  • Psychotherapy (cognitive behavioral therapy, etc.)
  • Exercise therapy
  • In reality, drug therapy centered on Chinese medicine is often performed.
  • As an accompanying symptom, analgesics are prescribed for body pain and headache, gastrointestinal drugs for gastrointestinal upset, and sleep-inducing agents for sleep disorders.
  • These drugs do not cure the syndrome fundamentally but are just “symptomatic treatments” to get rid of the symptoms.
  • It may be shown that “antioxidant treatment” and “anti-inflammatory treatment” are effective in the future.
  • For example, it has been reported that treatment with supplements such as vitamin C and coenzyme Q10, which have antioxidant effects, effectively prevents cell damage caused by inflammatory substances such as inflammatory cytokines and active oxygen in the body.
  • It is necessary to supplement minerals and vitamins related to energy metabolisms, such as iron and B vitamins, as a treatment.

In recent years, as a new treatment for depression, TMS treatment (transcranial magnetic stimulation method) certified in June 2019 is being studied for fatigue syndrome.

To prevent Chronic Fatigue Syndrome.

The cause of the syndrome is not yet known, and no preventive measures have been established. However, mental and physical fatigue accumulates when high-stress conditions continue. If you fall into a state of chronic fatigue, your immune system will be weakened, and you will be more likely to have physical and mental disorders. If you feel tired, try to take rest frequently. From a molecular nutritional point of view, it is also possible to regard chronic fatigue as mitochondrial dysfunction. Chronic fatigue manifests itself when mitochondrial function declines and cells do not get enough of the energy they need.


PRP regeneration therapy is a treatment that has effects such as tightening pores, improving wrinkles, dents, and sagging, improving even skin and acne scars, and improving thinning hair. It is said that there are almost no side effects because the treatment is completed in a short time without using a scalpel, and the blood collected from one’s blood is used. The patient’s blood is collected, and high-concentration platelet-rich plasma is extracted from the blood. According to the patient’s symptoms, growth factors are added to the extracted high-concentration PRP at a unique compounding ratio. Inject this into the target site in the optimal amount based on past case experience. In addition to having a relatively long-lasting effect, it also brings out the skin‘s regenerative power.

Expected effects of PRP

By injecting PRP into the area of ​​reduced function, skin cells are activated, and various things such as dents under the eyes, sagging, wrinkles, nasolabial folds, uneven skin, improvement of acne scars, treatment of thinning hair, etc. It can be expected to affect symptoms. The shape of your face does not change suddenly because it becomes beautiful without being noticed by others.

What is PRP?

PRP is abbreviated from Platelet Rich Plasma. In other words, it is plasma (the liquid component) that contains a large number of platelets in the blood. Imagine, for example, the healing of a wound when you cut your fingers or hands or rub your feet. Often, after a while, the blood stops, the wound closes, it becomes a scab, and it returns to its original state before you know it. The power of platelets plays a significant role in this flow. Platelets have the function of stopping blood, so people with low platelets have difficulty controlling the blood and slow the healing of wounds.

Platelets also create “growth factors” that act on various parts of the body. Growth factors from these platelets can heal wounds and restore clean skin before the injury. Growth factors decrease with age, so the ability to regenerate skin aging such as wrinkles and sagging cannot keep up, and “skin aging” progresses. However, by injecting PRP, which contains a large number of platelets, the skin cells are regenerated, the symptoms are improved, and troubles and worries are resolved.


How PRP works?

  • blood collection
  • centrifugation of blood
  • separation of platelets
  • extract platelets
  • inject PRP in the affected area

Vampire facial 

This is a regenerative medicine that uses high-concentration PRP generated from your blood, mixes it with a beautiful essence, makes fine holes in the entire face that cannot be seen with the naked eye, and applies it to the skin. In addition to the natural healing power of the human body that repairs the original wound, it is an advanced treatment that effectively acts on wrinkles, sagging, acne scars, pore opening, etc., by the effect of PRP.

Difference from other injection treatments

Treatments for wrinkles include hyaluronic acid injection, botox, and PRP skin regenerative medicine, but the mechanisms for improving wrinkles are different.

Hyaluronic acid

The hyaluronic acid injection is a treatment that lifts the skin from the inside and makes wrinkles less noticeable. Since hyaluronic acid is originally a component with large particles, unnatural swelling may be noticeable when injected into thin skin areas or shallow wrinkles. Also, although it is a safe and excellent treatment method, the injected part may touch a little hard.


Botox makes wrinkles less noticeable by relaxing the muscles that have been repeatedly strained to create facial expressions.

PRP skin regenerative medicine

On the other hand, PRP skin regenerative medicine is a treatment method that promotes skin regeneration and improves wrinkles by creating the “growth factor” of platelets in the blood.

How does PRP skin regenerative medicine work?

It penetrates a wide area and has a self-repairing ability to firm collagen fibers and give a natural finish without unevenness. It is a treatment that uses ingredients extracted from your blood, not a treatment that injects a foreign substance. The feel after injection is smooth, and it is possible to treat shallow skin areas and shallow wrinkles.

Growth factors

Growth factors have the function of activating and proliferating cells. There are many types of growth factors, but platelets contain the following:


Produces collagen and hyaluronic acid that repairs tissues


Promotes, the growth of cells (epithelial cells) such as skin and mucous membranes, creates new blood vessels (angiogenesis), and heals wounds (wound healing).


Cell proliferation, creating new blood vessels (angiogenesis), restoring blood vessels (vascular repair), creating collagen.


Increases or creates new cells (epithelial cells) such as skin and mucous membranes and cells on the inner surface of epithelial cells/blood vessels (vascular endothelial cells), and promotes wound healing (wound healing).

These growth factors are ingredients that can be expected to have a rejuvenating effect on blood vessels and skin, such as healing wounds, renewing cells, and producing collagen. 

Mechanism of PRP

PRP skin regeneration therapy is a treatment method that uses the action of growth factors contained in platelets to repair tissues and enhance the ability of tissues to regenerate and heal.

Since it uses its blood, it has almost no side effects. Therefore, it is used in cosmetic dermatology and in a wide range of fields such as orthopedics, plastic surgery, and dentistry. It is a treatment method that has attracted attention in recent years.

The patient’s blood is collected, and plasma containing a large number of platelets is taken out with a dedicated device and injected into the skin. PRP is injected little by little while sticking the needle several times to a problem with the skin. The amount of blood collected is 30 ml to 32 ml, but the number of injections varies depending on the patient, so please check with your doctor.

Disadvantages of PRP

PRP skin regeneration therapy has some potential disadvantages. The effect is not immediate and varies from person to person, so it may not be effective depending on the patient’s age and physical condition. After the treatment, the skin may become red. This will settle over time. If symptoms do not improve, return to the clinic immediately. If you are pregnant or breastfeeding, you cannot perform the procedure.


The meaning of “anti” is the opposite, and the meaning of “aging” is aging. Improving or preventing the physical symptoms of aging does not stop aging. In addition, it refers not only to the skin but also to the whole body such as the brain, blood vessels, and muscles.
Therefore, it seems that the various purposes of anti-aging are “to prevent aging” or “to slow down the speed of aging”.

What is aging?

After the age of 25, the growth speed of cells slows down and the number of dermis components(collagen) and muscles begin to decrease, so pores, sagging, fine lines, and dullness begin to stand out on the skin. Stain and dryness are also aging. In addition, not only the skin but also the internal organs,  muscles, bones, capillaries, and other whole-body aging begins, causing deterioration of internal organ functions, poor circulation, stiff shoulders, thinning hair, and other diseases. From here, anti-aging care can be tackled from daily life, so I would like to introduce the causes of the aging phenomenon and some countermeasures.

The causes of aging:

Changes in hormonal balance

There are two types of hormones that keep youth, “growth hormone” and “thyroid hormone“, which decrease with age. On the contrary, there are two types of hormones that accelerate aging, “adrenal corticosteroid “and ” thyroid stimulating hormone“, and these are increasing. Increasing or decreasing these four hormones promotes the symptoms of aging.

Reactive oxygen has the role of protecting the body by creating active oxygen when pathogenic bacteria, stress, ultraviolet rays, air pollution, etc. invade the body. But if it is made excessively, it is highly toxic and damages normal cells in the body. This causes so-called wrinkles and sagging and causes the aging phenomenon. This discovery will only extend healthy life expectancy, not the life expectancy itself. There is no doubt that aging is closely related to human death, but I don’t think that the lifespan of living things is determined by that alone, because humans have a mortality rate with age. I take it for granted, but that’s not always the case when looking at other animals. For example, turtles, young or old, have almost the same mortality rate. There are many other organisms that rarely show such an aging phenomenon, but each species has a maximum lifespan, which means that there are some factors other than aging that determine the maximum lifespan. But we don’t know what that factor is at this point.” If lifespan is not due to aging, even if aging can be completely prevented, the maximum lifespan does not change. Even so, healthy life expectancy is extended, and when you reach a certain age, you die like sleeping in good health. In a sense, it may be the ideal way to end life. As for the factors that determine lifespan, when cells divide more than a certain number of times, the telomeres at the ends of chromosomes become shorter, and the chromosomes are damaged, so the “telomeres theory” stops further cell division. There is a “coincidence theory” that it happened in the process of evolution, but there is no strong hypothesis at this time.

Medicines to stop aging

Bioidentical Hormone Replacement Therapy (BHRT)

This is the treatment for increasing the production of those hormones that decrease with age. If the amount of hormone secretion is optimal, youth and health can be maintained, but the amount of hormone secretion decreases with aging. Most of the aging phenomenon is due to the decrease in hormone secretion, and supplementing hormones to return to the optimum state is also effective for disease prevention and aging care. It is a treatment method that supplements hormones that have decreased due to internal use, injection, external use, etc., and keeps youth not only on the outside but also physically, mentally, and functionally, and maintains health and beauty.

PRP (platelet-rich plasma) therapy

In blood, there is a component called “platelets” that has the function of healing wounds. These platelets were allowed to condense activated at a high concentration, PRP contains many growth factors and has the power to promote cell growth. This power is the ” power to regenerate ” that maximizes the healing ability and tissue repair ability that human beings originally have and tries to repair damage automatically.


Stress Reduction

Today’s society faces many difficult problems such as changes in the industrial structure due to information technology, a serious recession after the burst of the bubble economy, globalization, and the arrival of a super-aging society. People are experiencing a lot of stress. Some conditions are caused by acute stress, while others are because of inappropriate lifestyle-related habits in chronic stress situations and shift to various secondary diseases. Therefore, stress management is as important from a preventive medical point of view as it is from a therapeutic medical point of view.

How to deal with stress, how stress is a very necessary condition for healthy lives. Appear the way of stress reaction effects of stress, unpleasant crisis psychological changes (anxiety, tension, depression, impatience, emotional reactions such as confusion) and the physiological responses associated with it (fatigue, malaise, headache, Palpitations, suffocation, dizziness, tremors, sweating and other autonomic symptoms) and behavioral reactions to relieve those unpleasant conditions (stressing, smoking or drinking alcohol to distract) all these reactions are closely related to lifestyles, and it is a well-known fact that inappropriate lifestyles lead to various physical illnesses.

Anti-aging and nutritional therapy

In order to keep your mind and your body healthy, diet selection is very important because your diet, digestion, and absorption is a very important factor in maintaining a healthy life. We provide you the complete nutritional guidance using careful diet plans. Holistic nutrition is to get healthy from the inside of the body by being close to each person’s environment, style, and way of thinking. We will guide you about a complete diet plan which is sufficient for you to provide enough nutrients which are essential for you to maintain a healthy lifestyle.


The word neurotransmitter is the combination of two words neuron, which means nerve cell, and transmitterwhich means transmission. If we defined it more precisely, a chemical molecule that transmits signals between nerve cells. The signal transmission from one nerve cell to the next occurs at special contact points called synapses. There is a gap between two synapses which is covered by neurotransmitters, and this gap is called the synaptic cleft.

The neurons are in contact and can communicate with each other. This is how the nerve cells in your body transmit electrical signals (excitation transmission).

How it works

It works like this in a step-by-step way.

  1. An electrical signal (action potential) reaches the presynaptic nerve cell. There, the neurotransmitters in membrane bubbles (which are vesicles) are stored.
  2. The vesicles fuse with the presynaptic membrane (fusion). As a result, the cell releases messenger substances into the synaptic gap (exocytosis).
  3. The neurotransmitters diffuse through the gap to the postsynaptic membrane. There are special docking points which are called receptors for the molecules. Only one specific molecule can bind to each receptor.
  4. So, there are specific receptors for every neurotransmitter. The molecule binds to this and thus leads to the opening of ion channels.
  5. Ions (charged particles) can now flow in or out through the ion channel. This creates an electrical signal again in the postsynaptic nerve cell. This can either have an excitatory  (EPSP) or an inhibiting (IPSP) effect on the cell.
  6. Special enzymes break down the neurotransmitters in the synaptic gap. Then the presynapse can receive the transmitters again and use them again.

Examples of Neurotransmitters

Many different neuronal messengers transmit signals in your body. Here, we give you an overview of important neurotransmitters, namely acetylcholine, glutamate, GABA, serotonin, and dopamine.

Acetylcholine Neurotransmitter

The neurotransmitter acetylcholine plays an important role in both the peripheral and central nervous systems. The peripheral nervous system mediates the signals between nerve and muscle cells at the so-called motor endplate. Acetylcholine is also one of the messenger substances most common in the brain (central nervous system, CNS).

In the autonomic nervous system, acetylcholine serves as a transmitter substance in neurons of the sympathetic and parasympathetic nervous systems.

There are two different acetylcholine receptors (cholinergic receptors) that influence the action of acetylcholine:

  • The nicotinic acetylcholine receptor
  • The muscarinic acetylcholine receptor.

Nicotinic receptors are ionotropic receptors, so they form ion channels themselves. The muscarinic receptor, on the other hand, is a metabotropic receptor that indirectly opens ion channels.

Glutamate Neurotransmitters and GABA Neurotransmitters

It is also the precursor of the transmitter γ-aminobutyric acid (GABA). The GABA synthesis takes place through the decarboxylation (removal of the carboxyl group) of the glutamic acid. GABA, in turn, is the most common inhibitory messenger substance in the central nervous system. This means that the glutamate effect and the GABA effect are opposite. It has an excitatory effect on the brain and is the most common excitatory transmitter.

The GABA system also works via ionotropic (GABA A) and metabotropic (GABA B) receptors.

Serotonin Neurotransmitter

The neurotransmitter serotonin is important for signal transmission in the central nervous system. Serotonin has an effect on sleep, pain perception, eating, sexual behavior, and emotions. In addition, it creates a good mood and serenity.

In depression, therefore, there is often a reduced serotonin concentration. That is why dopamine and serotonin are referred to as “happiness hormones.”

Dopamine Neurotransmitter

The neurotransmitter dopamine, along with adrenaline and noradrenaline, belongs to the so-called catecholamines. Dopamine synthesis takes place primarily in the adrenal medulla and in the hypothalamus in the brain. It is an intermediate in the production of norepinephrine and epinephrine from the amino acid tyrosine.

The dopamine effect can be seen in various control processes, such as motion control and the reward system. Therefore, the death of dopaminergic neurons in Parkinson’s disease leads to a sedentary lifestyle and even immobility. Hence, dopamine drugs are used to treat Parkinson’s disease. However, dopamine cannot cross the blood-brain barrier; therefore, dopamine precursors must be used.

Sympathetic Neurotransmitter

Dopamine can also increase the effectiveness of the sympathetic system. The sympathetic is a part of the autonomic nervous system that controls the activity of many organs. The neurotransmitters acetylcholine and norepinephrine regulate their neurons. So, you can see what important role neurotransmitters play throughout the body.

Neurotransmitter Testing

A neurotransmitter test is used to determine different neurotransmitters such as serotonin, norepinephrine, epinephrine, dopamine, GABA, PEA, histamine, adrenaline, and noradrenaline in the body. These neurotransmitter tests are used to evaluate the imbalances in the neurotransmitters in the body, and they also help determine which natural remedies or medications are appropriate. The neurotransmitter tests are conducted by taking samples of urine or saliva of the patient.


Neurotransmitters and neurotransmitter metabolites available for testing:



Abnormal levels have been associated with all types of depression, including persistent depressions, psychotic depression, postpartum depression, suicidal behaviors, aggression, chronic psychotropic medication use, and Parkinson’s Disease.


Dopamine Metabolite: Combined measurements of dopamine metabolites and dopamine have been used to evaluate the activity of dopamine neurotransmitters in dopaminergic neurons.

Dopamine Excitatory neuromodulator

Dopamine regulates epinephrine, also called adrenaline, and norepinephrine, also called noradrenaline, which is all catecholamines. Dopamine plays a crucial role in the pleasure/reward pathway (addiction and thrills), happiness, memory, and motor movement control.


works as an excitatory neuromodulator neurotransmitter. Epinephrine, also named adrenaline, is derived from the amine norepinephrine. As a neurotransmitter, epinephrine plays a crucial role in our body. It regulates attentiveness and mental focus.


Gamma-aminobutyric acid, usually named GABA, its a basic function is to prevent overstimulation of the body.


Chronic malfunctioning of glutamatergic neurotransmitters can cause neurodegenerative disorders. Its dysfunction may be involved in many neurodegenerative diseases and memory problems such as Huntington’s disease, Parkinson’s disease, Alzheimer’s, and vascular dementia. Other neurodegenerative disorders its imbalance may cause are amyotrophic lateral sclerosis, AIDS-neurodegeneration, Tourette’s syndrome, and Korsakoff syndrome.


Histamine works as an excitatory neurotransmitter. It is involved in the sleep/wake cycle and inflammatory response.


Norepinephrine works as an excitatory neurotransmitter. It is important for attention and focus.


Beta-phenylethylamine (PEA) works as an excitatory neurotransmitter generated from the amino acid phenylalanine.


Serotonin works as an inhibitory neurotransmitter. It is synthesized by enzymes that act on tryptophan or 5-HTTP.


Holistic medicine is a medical concept that the patient understands as closely linked to the environment system whose health is affected, among others, by psychological, social, environmental, and spiritual factors. Holistic medicine is a big topic of today’s science. Its concept is that a doctor should focus on the entire patient; this school of thought said that “we focus on the whole person” or “we work holistically.”

A person is healthy when everything is in perfect order physically, mentally, and socially. If you transfer this to holistic medicine, several health levels exist in interaction with one another. According to holistic medicine, a person is only healthy if all classes balance one another.

Five levels of health according to Holistic Approach.                     

This results in a holistic approach that can be applied to many levels of health.

What are levels of health according to the Holistic Approach?

Organic level or cell level

This means the body. With the proper diet, the supply of vitamins, and other essential substances, one can contribute to health here. Vitamins, minerals, trace elements, and all organic substances and hormones are essential elements for adequate health. Bacteria and viruses cause chronic infections; Brucellosis, and Typhoid Fever. Naturopathy and nutritional supplements are very helpful to eliminate these diseases.

The Nervous- electrical control of various systems

Countless electrical impulses and charges flow through the body at all times. Electrical impulses and our nervous system control almost all the functions in our body. In holistic medicine, it is assumed that internal and external interference fields can impair this electrical flow and thus affect health. Therefore, any electromagnetic influences from outside the body are possible factors that affect our health. Taking neuropathy treatment and dietary changes are essential to treat these issues.

Mental Level- Emotional & Psychological

This is primarily about emotional and mental health. Hypnosis, Meditations, application of different psychotherapies, and family consultations are beneficial to treat. Emotional parts of injuries are healed through individual approaches.

Energetic level

How much life energy does a person have? According to the holistic approach, you can achieve sound effects here with homeopathic remedies. This is called “life energy” that can be influenced, for example, by homeopathic treatments.

Spiritual level

By expanding consciousness, doctors can release blockages. Illness is almost a collection of various causes. At some point, the patience barrel is complete, and it then overflows, and the symptoms of the disease start to develop. Healing occurs when the barrel is less full, which often requires a holistic approach. Meditation and the expansion of consciousness that goes with it can make a significant contribution to health. Holistic medicine is used by many doctors, psychologists, and dentists to differentiate themselves from conventional medicine. However, unlike other healing methods, such as naturopathy or homeopathy, there is no 100 percent clear definition of holistic medicine. However, one can determine what it is not, its benefits, and the treatments.

Basics of Holistic Medicine

Compared to the traditional medicine method, holistic medicine does not only used to treat the symptoms of an illness but they are more focused on the causes. Within all of these medical specifications, a disease is defined as a mental and organic disorder as well. Treatment of patients usually lasts until the symptoms go away. However, since the cause is not addressed, a relapse may occur after a short period of relief.

Holistic medicine starts where conventional medicine leaves off. It takes a very close look at health and disease. As an example, if your soul is affected by something, the body could become ill. Everything is evidently in constant interaction with one another.

Areas of application

Holistic medicine usually has a vast spectrum of possible uses because it looks for factors that can make a person sick and reasonable measures for the person and promote health.

The medical history of a patient is significant here. From this, particular derivations of clinical pictures and individual therapeutic measures can be designed.

A holistic approach can be worthy, to recurring everyday complaints.

Therapeutic options in Holistic Medicine

If holistic medicine concludes an interaction between body, mind, and other external factors, this should be reflected in the various forms of therapy. The main focus should be on the body as well as on the mind to heal the body.

Orthomolecular medicine

This is a therapy with substances already present in the body, such as vitamins, minerals, and other enzymes.


In the subconscious, psychological problems that can affect the body are searched for.

Herbal medicines

They serve as a supplement or as an alternative to conventional treatments.


Electric surges with minimal charges are used to stimulate the muscles. They contribute to better and faster healing of sports injuries, wounds, or nervous system diseases.

This is just a small overview of the therapy options that are available with a holistic medical approach. The offers often differ from doctor to doctor.

Holistic medicine, not homeopathy

Far too often, holistic medical approaches are equated with alternative healing methods or even homeopathy. However, holistic medicine only uses individual elements from other alternative forms of healing and brings these together with findings and measures from conventional medicine, among other things.


Musculoskeletal Disorders are usually all disorders that affect muscles, bones, and joints. For example, back pain, herniated disc, and carpal tunnel syndrome also lie in this category, as do gout, osteoarthritis, and osteoporosis.

Back pain is highly one of the most widespread diseases with various causes, including psychological causes. The characteristics and causes are diverse. Some illnesses are caused due to work and meet the requirements of an occupational disease.

Work-related musculoskeletal disorders include the following.

Disc-related spinal diseases

Disc-related spinal diseases include

  • the diseases of the lumbar spine
  • the disorders of the cervical spine

These disorders are among the most commonly reported conditions of the musculoskeletal system.

Hypothenar-Thenar-Hammer Syndrome

Hypothenar-thenar-hammer syndrome is a circulatory disorder of the palm. It can occur either around ​​the ball of the little finger (hypothenar area) or the ball of the thumb (thenar area).

The cause may be blunt violence on the palm when using the hand, the edge of the hand, the ball of the little finger, or the thumb ball as a unique tool, or during activities with direct mechanical force.

Carpal tunnel syndrome

Carpal tunnel syndrome is chronic pressure damage to the wrist. It can result from repetitive manual activities involving flexion and extension of the wrists, from robust grasping, or from activities in which vibrations affect the hands and arms. If these effects occur individually or in combination, the risk of the disease can increase.

Work-related diseases and complaints of the musculoskeletal system are primarily so-called degenerative diseases; i.e., signs of wear and tear.

treatment of musculoskeletal disorders

These can be treated by Shockwave therapy

Historical development of shock wave therapy

Shock waves generated extracorporeally were used for the first time in the early eighties of the last century for breaking up kidney stones. The treatment method revolutionized urological therapy concepts for kidney stones and quickly developed into today’s way of choice.

Since the mid-1990s, shock waves have also been used to treat frequently occurring musculoskeletal disorders. A potent analgesic (pain-relieving) effect is decisive for the success of the therapy. Scientific studies have shown significant improvements due to this treatment in the complete healing of chronic complaints in muscles, tendons, ligaments, and joints. With basically the same technology as in the destruction of kidney stones, extracorporeal shock wave therapy (ESWT) can also have a specific effect on orthopedic disease and inflammation processes, tendinopathies (tendon irritation), and muscle hardening

Mode of action of the shock wave

The shock wave treatment action mechanism is based on the introduction of shock wave energy into tissue sections affected by injuries or inflammation. To do this, the attending physician uses a so-called applicator (handpiece), which is applied to the affected part of the body with light pressure. Now 2000 to 3000 focused pressure impulses are emitted into the deeper tissue layers below. Advanced devices use technology that can increase targeting accuracy and precision with a built-in ultrasound probe. Depending on the cause of the pain and the shock wave device used, a therapy session lasts between 5 and 15 minutes. The prices for the treatment depend on the type of device used (radial or focused shock wave) and the respective treatment effort.


For the following complaints, shockwave therapy can be used

Calcareous shoulder treatment

The calcareous shoulder is a chronic inflammation of the supraspinatus tendon caused by the accumulation of calcareous material in a cavity within the tendon. After the acute symptoms have subsided or in the chronic stage of the calcareous shoulder, shock wave treatment can be used. Often, this enables the limescale to be gently dissolved.

Tennis elbow

Tennis elbow is a complex inflammatory process around ​​the muscle attachments of the forearm extensor muscles. Often this is due to chronic overload due to one-sided work processes or permanent excessive physical activity. If relieving armbands, changes in daily routines and drug treatment have not improved, you should consider shock wave treatment. Often, 4-6 therapy sessions can already stimulate a lasting healing reaction.

Patellar tip syndrome

The patellar tip syndrome is a chronic inflammation of the patellar tendon caused by injuries or overloads that have not healed. Even surgical interventions often do not bring the desired healing success here. So, if physiotherapy, bandage treatment, or injection treatment have not provided sufficient relief, shock wave therapy can be used.

Achilles tendon

Permanent or recurring inflammation of the Achilles tendon can have a massive impact on quality of life. Every step causes pain; longer walking distances are only possible with painkillers. Because of years of irritation of this sensitive tendon structure, tendon ruptures can also occur, which require lengthy surgical treatment. Especially with active athletes or physically hardworking people, they can consider shock wave therapy at an early stage of the disease. Besides, gentle stretching exercises and high-quality insoles are helpful.

Muscle tension

Many acute and degenerative diseases of the joints and tendons are not only expressed in the form of restrictions in the affected locomotor function. These disorders are accompanied by massive tension in the adjacent muscle parts. Pain-related stress and negative environmental stimuli aggravate these muscular problems even more. In these cases, shock wave treatment can calm tension-related, local muscle swellings and permanently relieve the irritated tissue.

Possible complications and risks

Serious complications are not to be feared if shock wave therapy is used correctly. However, there may be temporary swelling or bleeding (bruise/hematoma) in the treatment area in some cases.

The following contraindications should be observed:

  • No use in the lungs/chest area.
  • No application via nerves and blood vessels.
  • Do not use in case of bleeding disorders or taking Marcum.

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